納豆激酶是從日本傳統發酵食物納豆中提取的活性成分。納豆在日本的食用歷史已經有1千多年，民間廣泛用來預防心腦血管疾病。這也解釋了為何日本是全球冠心病發病率最低的國家之一( 報告：UN Chronicle: The Atlas of Heart Disease & Stroke)。
在1980年，美國芝加哥大學研究員須見洋行博士發現納豆中有一種酶具有纖溶活性(溶解與心髒病發作和中風有關血栓的能力)，並將其命名為“納豆激酶”，意思是“納豆中的酶”。 此外，納豆激酶也有助於解決高血黏問題， 這是心髒病和高血壓發展中最常被忽略的症狀之一。
確保通是以100%純濃縮納豆激酶NSK-SD®製成。 NSK-SD®由納豆激酶產品鼻祖，日本生物科學研究所研製，並通過清真和NSF認證。此外，NSK-SD®納豆激酶是從非轉基因黃豆自然發酵過程中通過專利技術提純。 它也是唯一使用專利枯草芽孢桿菌納豆原菌株發酵，以製成100%純正納豆激酶，並具有高生物利用度和穩定性。
每克NSK-SD®具有超過20,000 FU納豆激酶活性。每日所建議的攝取量是至少2,000 FU，相當於100 mg NSK-SD®。
FU(纖維蛋白單位) - 一種活性單位，用於評估酵素在體外溶解纖維蛋白的能力。
• 高安全性和穩定性。 通過臨床試驗驗證、廣泛研究和將近20年的安全記錄。納豆激酶NSK-SD®儲存在室溫下活性穩定長達42個月，在40℃下則穩定18個月。
(Altern Ther Health Med.19(3)：16-19(2013))
在一項臨床試驗，健康受試者(30- 40餘歲)在空腹的情況下口服2,000 FU納豆激酶NSK-SD®，並測量他們的血流量。間隔2週後，同樣的受試者在相同的情況下口服無效對照劑。結果顯示，納豆激酶NSK-SD®增加血液流動。這表明NSK-SD®可促進健康血液循環。
在一項臨床試驗，患有高血壓前期或1期高血壓(收縮壓130 - 159 mmHg)和未經治療的受試者(20-80歲)每日口服2,000 FU納豆激酶NSK-SD®或無效對照劑長達8週。與對照組相比，納豆激酶NSK-SD®降低收縮壓和舒張壓。這表明了納豆激酶可能在預防和治療高血壓方面能發揮關鍵作用。
• 血液循環不良，如手腳冰冷、發麻或腫脹、肌肉痙攣，肩膀僵硬、靜脈曲張，持續疲勞 等
Bozo Research Center, I. 2004. Report: 13-week oral toxicity study of Nattokinase DS (NSK-SD) in rats. B-5170.
Fuji Biomedix, L. 2002. Final Report: Oral repeated dose 28-day toxicity study of Nattokinase DS in rats. FBM02-2704.
Fuji Biomedix, L. 2003a. Final report: Reverse-mutation assay in bacteria. FBM 02-8766.
Fuji Biomedix, L. 2003b. Final report: Chromosomal aberration test. FBM 02-8767.
Jeske, W. et al. 2011. Evaluating the effects of nattokinase on C-reactive protein levels in adults at risk forcardiovascular disease. Unpublished work.
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Q: What is VesseCLEAR Nattokinase NSK-SD®?
A: Nattokinase is an enzyme extracted from a popular traditional Japanese food “natto”, that dates back more than 1000 years. Nattokinase is proven to have strong fibrinolytic activity that can help to dissolve fibrin, a web-like structure that forms the basis of blood clot. Since nattokinase is effective in breaking down blood clot (thrombus), it has been used as a natural remedy for heart and circulatory diseases.
NSK-SD® (Natural Super Kinase-Sprayed Dried) is a proprietary nattokinase extracted from non-GMO soybeans which were fermented with a patented strain of Bacillus subtilis natto, via a proprietary process to result in high purity and maximal bioavailability and stability (Patents: JP3834048, JP3881494). The safety and efficacy of NSK-SD® has been demonstrated in numerous human clinical studies.
VesseCLEAR is an encapsulation of pure concentrated nattokinase NSK-SD® developed by Japan Bio Science Laboratory Co., Ltd, the world leader and pioneer in nattokinase.
Q: Does VesseCLEAR Nattokinase NSK-SD® contain vitamin K2?
A: No, it does not contain vitamin K2. When looking for a quality nattokinase, always look for the one with the vitamin K2 removed. Natto is one of the richest sources of vitamin K2 that
may increase blood clotting. Vitamin K2 is also known to reduce the effectiveness of
Warfarin (anticoagulant) and thus, avoided by Warfarin users. By removing most or all of
the vitamin K2 during the production of NSK-SD®, any potential adverse drug interactions with Warfarin may be eliminated. However, always consult physician before taking VesseCLEAR with medications.
Q: Does VesseCLEAR Nattokinase NSK-SD® contain any soy?
A: Although the production of nattokinase involves the use of soy medium, the remaining soy left after nattokinase extraction and purification is very minimal. However, we do advise you to consult your physician if you have an allergy to soy.
Q: I am suffering from gout. Would VesseCLEAR Nattokinase NSK-SD® worsen my gout problem?
A: No, it would not. Eating natto food which is high in purine may increase blood uric acid levels, and in turn, exacerbate gout. However, VesseCLEAR Nattokinase NSK-SD® is an enzyme extracted and purified from natto through a patented process and it is free of purine.
Q: How safe is VesseCLEAR Nattokinase NSK-SD®?
A: The safety of VesseCLEAR Nattokinase NSK-SD® has been tested in various human clinical studies. Besides, the raw materials used in the making of nattokinase NSK-SD® are of non-animal origin and has been certified non-GMO, which means that no genetically modified organisms were used in the manufacturing process.
Q: How long does it take to see the effect of VesseCLEAR Nattokinase NSK-SD®?
A: As VesseCLEAR is a natural supplement and not a medicine, its effects may vary from person to person. However, most users would be able to see positive improvement at around 6 to 8 weeks.
Q: Does VesseCLEAR Nattokinase NSK-SD® improve blood circulation of elderly person?
A: Yes, VesseCLEAR Nattokinase NSK-SD® helps improve blood circulation. Healthy blood circulation is when blood flows smoothly throughout the body. Increasing age is
associated with decreased fibrinolytic activity and increased platelet aggregability. Thus, blood thickens as we get older. Nattokinase NSK-SD® helps dissolve fibrin (a main component of blood clot) and suppress platelet aggregation, hence supporting healthy blood flow and circulation.
Q: Does VesseCLEAR Nattokinase NSK-SD® help support healthy blood pressure?
A: Yes. VesseCLEAR Nattokinase NSK-SD® was clinically proven to reduce elevated blood pressure in hypertensive subjects. NSK-SD® is powerful enzyme that breaks up fibrin clotting agents naturally. This action could help improve blood flow and thus, support healthy
blood pressure. However, those taking prescription blood thinner are advised to consult physician before taking VesseCLEAR.
Q: If VesseCLEAR Nattokinase NSK-SD® could break up blood clots, will the clots spread around and create health problem elsewhere?
A: No, it will not. VesseCLEAR Nattokinase NSK-SD® tends to first cut the clot away from blood vessel and fibrin in the clot is dissolved and then excreted by the kidneys. Thus, it will not spread to other parts of the body and create a stroke or any health problems.
Q: Why should I use VesseCLEAR Nattokinase NSK-SD® to maintain optimum blood flow when I can use aspirin which is much cheaper?
A: Aspirin is an antiplatelet drug that prevents platelets from clumping together to form a clot. This direct effect of aspirin on blood coagulation may lessen the body’s ability to stop bleeding when you are cut, scratched or bruised. Prolonged use of aspirin has also been associated with gastrointestinal bleeding, brain haemorrhage and allergic reactions.
On the other hand, VesseCLEAR Nattokinase NSK-SD® is a natural supplement which helps the body to improve blood circulation by breaking down harmful blood clot. It does not adversely affect blood coagulation and wound healing. Thus, it can be taken safely, even
on a long-term basis, without posing a risk of haemorrhage. Besides, VesseCLEAR can
also be used in conjunction with aspirin, but you are always advised to consult your physician before doing so.
Q: Who can take VesseCLEAR Nattokinase NSK-SD®?
A: VesseCLEAR Nattokinase NSK-SD® is intended for adult use on a regular basis, especially those who are over 40 years old, highly stressed, have relatively high blood pressure or high blood viscosity. It is also suitable for those who have higher risk or compromised cardiovascular health such as irregular heartbeat, chest pain, stroke etc. People with poor blood circulation such as cold or numb hands and feet, varicose vein as well as deep vein thrombosis are also encouraged to take VesseCLEAR. Please consult your physician before taking any dietary supplements if you have or have had any health condition.
Q: What is the recommended daily dosage of VesseCLEAR Nattokinase NSK-SD®?
A: As a prophylactic approach, the recommended dosage is minimum 2,000 FU (100mg) VesseCLEAR Nattokinase NSK-SD®.
Q: What does FU stand for?
A: FU stands for fibrin units, which is an activity unit that quantifies an enzyme’s ability to lyse fibrin found in blood clots. Nattokinase is measured in FU as opposed to milligrams or international units. This is officially adopted by the Japan NattoKinase Association (JNKA) and the Japan Health and Nutritionn Food Association (JHFA) as the standard measurement of nattokinase activity.
Q: Does VesseCLEAR Nattokinase NSK-SD® require a prescription?
A: No, VesseCLEAR Nattokinase NSK-SD® is a natural supplement. It is not a medicine and hence, no prescription is required.
Q: When should I take VesseCLEAR Nattokinase NSK-SD®?
A: VesseCLEAR Nattokinase NSK-SD® is preferably taken after dinner or before bedtime. Since thrombosis (formation of blood clot in blood vessel) is more likely to happen at dawn and most heart attacks and strokes happen in the early morning, this should grant a greater degree of protection.
Q: Is VesseCLEAR Nattokinase NSK-SD® suitable for vegetarians?
A: Yes, it is suitable for vegetarians. VesseCLEAR Nattokinase NSK-SD® is made with vegan ingredients.
Q: Can I take VesseCLEAR Nattokinase NSK-SD® while I am on medication?
A: Yes, you can. However, do keep a 2-hour gap between VesseCLEAR Nattokinase NSK-SD® and medicine to ensure that the efficacy of VesseCLEAR is not compromised. Individuals on blood thinning therapy should seek medical advice before taking.
Q: Can I take VesseCLEAR Nattokinase NSK-SD® while I am taking blood thinners?
A: According to clinical studies, VesseCLEAR Nattokinase NSK-SD® (3 doses of 2,000 FU a day) was safely administered along with heparin (3,800 IU twice a day by hypodermic injection) and antiplatelet drug (150 – 325 mg aspirin or clopidogrel). Besides, nattokinase NSK-SD® was also safely administred as a complement to warfarin at dosage up to
3,400 FU (2 doses of 1,700 FU) per day. However, the use of VesseCLEAR along with medications should be done under the close supervision of a physician and regular blood monitoring is important. It is possible that taking nattokinase while you are taking blood thinner may reduce the required dosage for the medication. Please consult your physician for guidance on this.
Q: Is VesseCLEAR Nattokinase NSK-SD® safe for use during pregnancy and nursing?
A: VesseCLEAR Nattokinase NSK-SD® has not been studied for use during pregnancy and nursing. If you are pregnant or nursing, we strongly encourage you to consult your physician before taking any supplements.
Q: What is the difference between nattokinase and lumbrokinase? Can they be taken at the same time?
A: The major difference between lumbrokinase and nattokinase is the source of origination Nattokinase originates from natto (soybeans) whereas lumbrokinase comes from cells of intestinal tissue and fluid of earthworm. However, lumbrokinase acts similarly to nattokinase, that is to prevent and dissolve blood clots. Since they have similar actions, usually one or the other is used. Besides, any contraindications to using both of them concurrently is still unknown and thus, you are not advisable to use them at the same time.
Q: Ginkgo is also known to improve blood flow. How does nattokinase different from ginkgo?
A: Although both ginkgo and nattokinase help improve blood flow, both of them work through different pathways. Ginkgo appears to dilate small blood vessels and make blood less sticky, thereby increasing blood flow to the legs, ears, eyes and brain. On the other hand, nattokinase increases blood flow by dissolving blood clot in blood vessels, inhibiting platelet aggregation and delaying thrombus (blood clot) formation. Besides, research found that ginkgo does not prevent heart attack, stroke or death, whereas nattokinase is suggested by research as a powerful prophylactic approach for heart attack and stroke.
✓ Breaks down blood clots formed in blood vessels and enhances anticoagulant activity
In a human clinical trial, healthy young men (22.3 ± 0.6 years old) received either a single dose of 2,000 FU nattokinase NSK-SD® or placebo and blood samples were collected and analysed. Results showed that nattokinase NSK-SD® enhances fibrinolysis (breaking down of blood clots) and anticoagulation.
✓ Supports healthy blood pressure
In a human clinical trial, subjects (18 – 85 years) with elevated blood pressure (BP; systolic BP ≥130 or diastolic BP ≥ 90 mmHg) consumed 2,000 FU/day nattokinase NSK-SD® or placebo for 8 weeks and their blood was collected. Consumption of NSK-SD® was associated with a reduction in both systolic and diastolic BP as well as von Willebrand factor (vWF), a cardiovascular risk marker.
✓ Suppresses platelet aggregation and thrombus (blood clot) formation
In another study, the effects of nattokinase NSK-SD® on in vitro platelet aggregation and in vivo thrombosis were investigated in comparison with aspirin, a medicine that helps prevent blood clots in arteries. Nattokinase NSK-SD® moderately inhibits platelet aggregation and delays thrombosis following oxidative arterial wall injury, suggesting its beneficial effect on improving blood flow without adverse effects.
Platelet-rich plasma was incubated with nattokinase NSK-SD® and aggregation inducers collagen and thrombin, and the platelet aggregation rate was analysed. Nattokinase significantly inhibited both the collagen- and thrombin-induced platelet aggregation.
Subjects were orally administered with nattokinase NSK-SD® or aspirin for 1 week, and their major blood vessels in the neck were exposed. Arterial thrombosis (blood clot formation in artery) was induced by applying FeCl3 outside the arterial wall for 10 min, and the blood flow was monitored. Nattokinase delayed the FeCl3-induced arterial blockage in a dose-dependent manner with a high dose (500 mg/kg) of nattokinase fully suppressed the blockage, as achieved with aspirin (30 mg/kg).
✓ Inactivates plasminogen activator inhibitor 1 (PAI-1), a marker of thrombosis
A rise in blood plasminogen activator inhibitor type-1 (PAI-1) level has been shown to precede the occurrence of heart attack. Factors such as obesity, high blood sugar, cholesterol and triglycerides, stress and inflammation may increase PAI-1, preventing blood clots from being broken down easily. Thus, PA1-1 appears to be a risk factor for the development and recurrence of thrombotic cardiovascular diseases. In an in vitro study, nattokinase appeared to cleave and inactivate PAI-1 in a dose-dependent manner.
✓ Improves cardiovascular health along with blood thinners
In a human clinical trial, adult patients (average 53.3 years old) with acute ischaemic stroke received 2,000 FU nattokinase NSK-SD® 3 times (total 6,000 FU) a day at 8-hour interval for 7 days. Besides, during these 7 days, 0.4ml low molecular weight heparin (anti-factor Xa, 3,800 IU) 2 times a day by hypodermic injection and low-dose aspirin (150 – 325mg) or clopidogrel were also administered. Heparin (anticoagulant drug), aspirin and clopidogrel (anti-platelet drugs) are blood thinners. All patients were hospitalized within 6 hours of stroke occurrence and the treatment was administered after hospitalization. The overall efficacy data suggests that nattokinase does not lead to progression of underlying stroke. Instead, the combined intake is suggested to enhance fibrinolysis (breaking down of blood clots) and the beneficial effects on stroke patients were observed.
In another human clinical trial, patients with cardiovascular disease (CVD) who were taking warfarin potassium tablets at a maintenance dose (1.5 < PT-INR < 3.0) received 2 doses of 1,700 FU nattokinase NSK-SD® after breakfast and dinner per day (3,4000 FU/day) or placebo for 6 months. Some of these patients showed improvement in clinical symptoms (i.e. shortness of breath, cold hands and feet) and biochemical profiles, including activated partial thromboplastin time (aPTT), prothrombin time (PT), D-dimer and plasmin inhibitor complex (PIC). No side effects were observed in all patients taking nattokinase. This study suggests that proper use of nattokinase is safe and effective for CVD patients who are taking warfarin.
Common Remedies for Circulatory Health in the Market
1) Blood Thinners (Medications)
Blood thinners are prescribed medicines that prevent blood clots from forming. They also keep existing blood clots from getting larger. There are 2 main types of blood thinners –
anticoagulants and antiplatelet drugs.
• Anticoagulants, such as heparin or warfarin slows down the body’s process of making clots.
• Antiplatelet drugs, such as aspirin or clopidogrel prevents platelets from clumping together to form a clot.
However, blood thinners may cause side effects in some people. Serious bleeding is the most common reaction - heavy periods, bleeding gums, prolonged
bleeding from a cut, etc. Other possible side effects include dizziness, muscle weakness, hair loss or rashes. Besides, the presence of blood thinners in body system can increase the risk of internal bleeding after an injury, even if external bleeding did not occur.
Although there are many types of Nattokinase available in the market, did you know that nattokinase activity may decrease when mixed with certain foods/ingredients such as red yeast rice (Monascus ruber-fermented rice). Before you make your purchase, do ensure that the supplement you chose is of pure nattokinase to ensure maximum efficacy.
Nattokinase activity may decrease to 0% when mixed with certain foods/ingredients such asblack vinegar, apple vinegar and vitamin C. Before you make your purchase, do ensure that the supplement you choose is of pure nattokinase to ensure maximum efficacy.
Did you know that natto is also linked to longevity?
(Biosci Biotechnol Biochem 77(2): 392-394 (2013)).