在新加坡，每天有16人死于心血管疾病(心脏病和中风)。 根据2016年的统计数据，心血管疾病占所有死亡人数的29.5％，与癌症所造成的死亡率相似(29.6％)。 换句话说，每3位新加坡人就有1位死于心脏病或中风。 因此，早期预防非常重要。
纳豆激酶是从日本传统发酵食物纳豆中提取的活性成分。 纳豆在日本的食用历史已经有1千多年，民间广泛用来预防心脑血管疾病。这也解释了为何日本是全球冠心病发病率最低的国家之一( 报告：UN Chronicle: The Atlas of Heart Disease & Stroke)。
每克NSK-SD®具有超过20,000 FU纳豆激酶活性。每日所建议的摄取量是至少2,000 FU，相当于100 mg NSK-SD®。
FU(纤维蛋白单位) - 一种活性单位，用于评估酵素在体外溶解纤维蛋白的能力。
• 100％天然及素食配方。无辐射，不含维生素K2、嘌呤和纳豆特有的刺激性气味。维生素K2可会增加血液凝固，并会对华法林(血液稀释剂)起拮抗作用，并降低它们的功效。 嘌呤则是高尿酸和痛风的风险因素。
• 高安全性和稳定性。 通过临床试验验证、广泛研究和将近20年的安全记录。纳豆激酶NSK-SD®储存在室温下活性稳定长达42个月，在40℃下则稳定18个月。
(Altern Ther Health Med.19(3)：16-19(2013))
在一项临床试验，健康年轻男性(22.3±0.6岁)口服单次剂量2,000 FU纳豆激酶NSK-SD®或无效对照剂后，抽取血液样本进行分析。 结果显示，纳豆激酶NSK-SD®增强纤维蛋白溶解(分解血凝块)和抗凝能力。
在一项临床试验，健康受试者(30- 40余岁)在空腹的情况下口服2,000 FU纳豆激酶NSK-SD®，并测量他们的血流量。 间隔2周后，同样的受试者在相同的情况下口服无效对照剂。 结果显示，纳豆激酶NSK-SD®增加血液流动。这表明NSK-SD®可促进健康血液循环。
在一项临床试验，患有高血压前期或1期高血压(收缩压130 - 159 mmHg)和未经治疗的受试者(20-80岁)每日口服2,000 FU纳豆激酶NSK-SD®或无效对照剂长达8周。 与对照组相比，纳豆激酶NSK-SD®降低收缩压和舒张压。这表明了纳豆激酶可能在预防和治疗高血压方面能发挥关键作用。
在一项临床试验，心血管疾病高危受试者口服单次剂量2,000 FU纳豆激酶NSK-SD®，并进行血液检测。 结果显示，纳豆激酶有潜质正常化hs-CRP水平。
• 血液循环不良，如手脚冰冷、发麻或肿胀、肌肉痉挛，肩膀僵硬、静脉曲张，持续疲劳 等
Bozo Research Center, I. 2004. Report: 13-week oral toxicity study of Nattokinase DS (NSK-SD) in rats. B-5170.
Fuji Biomedix, L. 2002. Final Report: Oral repeated dose 28-day toxicity study of Nattokinase DS in rats. FBM02-2704.
Fuji Biomedix, L. 2003a. Final report: Reverse-mutation assay in bacteria. FBM 02-8766.
Fuji Biomedix, L. 2003b. Final report: Chromosomal aberration test. FBM 02-8767.
Jeske, W. et al. 2011. Evaluating the effects of nattokinase on C-reactive protein levels in adults at risk forcardiovascular disease. Unpublished work.
含量：241毫克x 30 植物胶囊
注意：纳豆激酶NSK-SD®来源于大豆，最终产品可能含有微量大豆成分。 如果您对大豆过敏，请谨慎使用。 正在服用血液稀释药物应在服用確保通之前先咨询医生。强烈建议在安排手术前至少两周停止服用確保通。膳食补充品不能替代健康饮食。如果您正怀孕、哺乳或服用任何药物，
Q: What is VesseCLEAR Nattokinase NSK-SD®?
A: Nattokinase is an enzyme extracted from a popular traditional Japanese food “natto”, that dates back more than 1000 years. Nattokinase is proven to have strong fibrinolytic activity that can help to dissolve fibrin, a web-like structure that forms the basis of blood clot. Since nattokinase is effective in breaking down blood clot (thrombus), it has been used as a natural remedy for heart and circulatory diseases.
NSK-SD® (Natural Super Kinase-Sprayed Dried) is a proprietary nattokinase extracted from non-GMO soybeans which were fermented with a patented strain of Bacillus subtilis natto, via a proprietary process to result in high purity and maximal bioavailability and stability (Patents: JP3834048, JP3881494). The safety and efficacy of NSK-SD® has been demonstrated in numerous human clinical studies.
VesseCLEAR is an encapsulation of pure concentrated nattokinase NSK-SD® developed by Japan Bio Science Laboratory Co., Ltd, the world leader and pioneer in nattokinase.
Q: Does VesseCLEAR Nattokinase NSK-SD® contain vitamin K2?
A: No, it does not contain vitamin K2. When looking for a quality nattokinase, always look for the one with the vitamin K2 removed. Natto is one of the richest sources of vitamin K2 that may increase blood clotting. Vitamin K2 is also known to reduce the effectiveness of Warfarin (anticoagulant) and thus, avoided by Warfarin users. By removing most or all ofthe vitamin K2 during the production of NSK-SD®, any potential adverse drug interactions with Warfarin may be eliminated. However, always consult physician before taking VesseCLEAR with medications.
Q: Does VesseCLEAR Nattokinase NSK-SD® contain any soy?
A: Although the production of nattokinase involves the use of soy medium, the remaining soy left after nattokinase extraction and purification is very minimal. However, we do advise you to consult your physician if you have an allergy to soy.
Q: I am suffering from gout. Would VesseCLEAR Nattokinase NSK-SD® worsen my gout problem?
A: No, it would not. Eating natto food which is high in purine may increase blood uric acid levels, and in turn, exacerbate gout. However, VesseCLEAR Nattokinase NSK-SD® is an enzyme extracted and purified from natto through a patented process and it is free of purine.
Q: How safe is VesseCLEAR Nattokinase NSK-SD®?
A: The safety of VesseCLEAR Nattokinase NSK-SD® has been tested in various human clinical studies. Besides, the raw materials used in the making of nattokinase NSK-SD® are of non-animal origin and has been certified non-GMO, which means that no genetically modified organisms were used in the manufacturing process.
Q: How long does it take to see the effect of VesseCLEAR Nattokinase NSK-SD®?
A: As VesseCLEAR is a natural supplement and not a medicine, its effects may vary from person to person. However, most users would be able to see positive improvement at around 6 to 8 weeks.
Q: Does VesseCLEAR Nattokinase NSK-SD® improve blood circulation of elderly person?
A: Yes, VesseCLEAR Nattokinase NSK-SD® helps improve blood circulation. Healthy blood circulation is when blood flows smoothly throughout the body. Increasing age is
associated with decreased fibrinolytic activity and increased platelet aggregability. Thus, blood thickens as we get older. Nattokinase NSK-SD® helps dissolve fibrin (a main component of blood clot) and suppress platelet aggregation, hence supporting healthy blood flow and circulation.
Q: Does VesseCLEAR Nattokinase NSK-SD® help support healthy blood pressure?
A: Yes. VesseCLEAR Nattokinase NSK-SD® was clinically proven to reduce elevated blood pressure in hypertensive subjects. NSK-SD® is powerful enzyme that breaks up fibrin clotting agents naturally. This action could help improve blood flow and thus, support healthy
blood pressure. However, those taking prescription blood thinner are advised to consult physician before taking VesseCLEAR.
Q: If VesseCLEAR Nattokinase NSK-SD® could break up blood clots, will the clots spread around and create health problem elsewhere?
A: No, it will not. VesseCLEAR Nattokinase NSK-SD® tends to first cut the clot away from blood vessel and fibrin in the clot is dissolved and then excreted by the kidneys. Thus, it will not spread to other parts of the body and create a stroke or any health problems.
Q: Why should I use VesseCLEAR Nattokinase NSK-SD® to maintain optimum blood flow when I can use aspirin which is much cheaper?
A: Aspirin is an antiplatelet drug that prevents platelets from clumping together to form a clot. This direct effect of aspirin on blood coagulation may lessen the body’s ability to stop bleeding when you are cut, scratched or bruised. Prolonged use of aspirin has also been associated with gastrointestinal bleeding, brain haemorrhage and allergic reactions.
On the other hand, VesseCLEAR Nattokinase NSK-SD® is a natural supplement which helps the body to improve blood circulation by breaking down harmful blood clot. It does not adversely affect blood coagulation and wound healing. Thus, it can be taken safely, even
on a long-term basis, without posing a risk of haemorrhage. Besides, VesseCLEAR can
also be used in conjunction with aspirin, but you are always advised to consult your physician before doing so.
Q: Who can take VesseCLEAR Nattokinase NSK-SD®?
A: VesseCLEAR Nattokinase NSK-SD® is intended for adult use on a regular basis, especially those who are over 40 years old, highly stressed, have relatively high blood pressure or high blood viscosity. It is also suitable for those who have higher risk or compromised cardiovascular health such as irregular heartbeat, chest pain, stroke etc. People with poor blood circulation such as cold or numb hands and feet, varicose vein as well as deep vein thrombosis are also encouraged to take VesseCLEAR. Please consult your physician before taking any dietary supplements if you have or have had any health condition.
Q: What is the recommended daily dosage of VesseCLEAR Nattokinase NSK-SD®?
A: As a prophylactic approach, the recommended dosage is minimum 2,000 FU (100mg) VesseCLEAR Nattokinase NSK-SD®.
Q: What does FU stand for?
A: FU stands for fibrin units, which is an activity unit that quantifies an enzyme’s ability to lyse fibrin found in blood clots. Nattokinase is measured in FU as opposed to milligrams or international units. This is officially adopted by the Japan NattoKinase Association (JNKA) and the Japan Health and Nutritionn Food Association (JHFA) as the standard measurement of nattokinase activity.
Q: Does VesseCLEAR Nattokinase NSK-SD® require a prescription?
A: No, VesseCLEAR Nattokinase NSK-SD® is a natural supplement. It is not a medicine and hence, no prescription is required.
Q: When should I take VesseCLEAR Nattokinase NSK-SD®?
A: VesseCLEAR Nattokinase NSK-SD® is preferably taken after dinner or before bedtime. Since thrombosis (formation of blood clot in blood vessel) is more likely to happen at dawn and most heart attacks and strokes happen in the early morning, this should grant a greater degree of protection.
Q: Is VesseCLEAR Nattokinase NSK-SD® suitable for vegetarians?
A: Yes, it is suitable for vegetarians. VesseCLEAR Nattokinase NSK-SD® is made with vegan ingredients.
Q: Can I take VesseCLEAR Nattokinase NSK-SD® while I am on medication?
A: Yes, you can. However, do keep a 2-hour gap between VesseCLEAR Nattokinase NSK-SD® and medicine to ensure that the efficacy of VesseCLEAR is not compromised. Individuals on blood thinning therapy should seek medical advice before taking.
Q: Can I take VesseCLEAR Nattokinase NSK-SD® while I am taking blood thinners?
A: According to clinical studies, VesseCLEAR Nattokinase NSK-SD® (3 doses of 2,000 FU a day) was safely administered along with heparin (3,800 IU twice a day by hypodermic injection) and antiplatelet drug (150 – 325 mg aspirin or clopidogrel). Besides, nattokinase NSK-SD® was also safely administred as a complement to warfarin at dosage up to
3,400 FU (2 doses of 1,700 FU) per day. However, the use of VesseCLEAR along with medications should be done under the close supervision of a physician and regular blood monitoring is important. It is possible that taking nattokinase while you are taking blood thinner may reduce the required dosage for the medication. Please consult your physician for guidance on this.
Q: Is VesseCLEAR Nattokinase NSK-SD® safe for use during pregnancy and nursing?
A: VesseCLEAR Nattokinase NSK-SD® has not been studied for use during pregnancy and nursing. If you are pregnant or nursing, we strongly encourage you to consult your physician before taking any supplements.
Q: What is the difference between nattokinase and lumbrokinase? Can they be taken at the same time?
A: The major difference between lumbrokinase and nattokinase is the source of origination Nattokinase originates from natto (soybeans) whereas lumbrokinase comes from cells of intestinal tissue and fluid of earthworm. However, lumbrokinase acts similarly to nattokinase, that is to prevent and dissolve blood clots. Since they have similar actions, usually one or the other is used. Besides, any contraindications to using both of them concurrently is still unknown and thus, you are not advisable to use them at the same time.
Q: Ginkgo is also known to improve blood flow. How does nattokinase different from ginkgo?
A: Although both ginkgo and nattokinase help improve blood flow, both of them work through different pathways. Ginkgo appears to dilate small blood vessels and make blood less sticky, thereby increasing blood flow to the legs, ears, eyes and brain. On the other hand, nattokinase increases blood flow by dissolving blood clot in blood vessels, inhibiting platelet aggregation and delaying thrombus (blood clot) formation. Besides, research found that ginkgo does not prevent heart attack, stroke or death, whereas nattokinase is suggested by research as a powerful prophylactic approach for heart attack and stroke.
✓ Breaks down blood clots formed in blood vessels and enhances anticoagulant activity
In a human clinical trial, healthy young men (22.3 ± 0.6 years old) received either a single dose of 2,000 FU nattokinase NSK-SD® or placebo and blood samples were collected and analysed. Results showed that nattokinase NSK-SD® enhances fibrinolysis (breaking down of blood clots) and anticoagulation.
✓ Supports healthy blood pressure
In a human clinical trial, subjects (18 – 85 years) with elevated blood pressure (BP; systolic BP ≥130 or diastolic BP ≥ 90 mmHg) consumed 2,000 FU/day nattokinase NSK-SD® or placebo for 8 weeks and their blood was collected. Consumption of NSK-SD® was associated with a reduction in both systolic and diastolic BP as well as von Willebrand factor (vWF), a cardiovascular risk marker.
✓ Suppresses platelet aggregation and thrombus (blood clot) formation
In another study, the effects of nattokinase NSK-SD® on in vitro platelet aggregation and in vivo thrombosis were investigated in comparison with aspirin, a medicine that helps prevent blood clots in arteries. Nattokinase NSK-SD® moderately inhibits platelet aggregation and delays thrombosis following oxidative arterial wall injury, suggesting its beneficial effect on improving blood flow without adverse effects.
Platelet-rich plasma was incubated with nattokinase NSK-SD® and aggregation inducers collagen and thrombin, and the platelet aggregation rate was analysed. Nattokinase significantly inhibited both the collagen- and thrombin-induced platelet aggregation.
Subjects were orally administered with nattokinase NSK-SD® or aspirin for 1 week, and their major blood vessels in the neck were exposed. Arterial thrombosis (blood clot formation in artery) was induced by applying FeCl3 outside the arterial wall for 10 min, and the blood flow was monitored. Nattokinase delayed the FeCl3-induced arterial blockage in a dose-dependent manner with a high dose (500 mg/kg) of nattokinase fully suppressed the blockage, as achieved with aspirin (30 mg/kg).
✓ Inactivates plasminogen activator inhibitor 1 (PAI-1), a marker of thrombosis
A rise in blood plasminogen activator inhibitor type-1 (PAI-1) level has been shown to precede the occurrence of heart attack. Factors such as obesity, high blood sugar, cholesterol and triglycerides, stress and inflammation may increase PAI-1, preventing blood clots from being broken down easily. Thus, PA1-1 appears to be a risk factor for the development and recurrence of thrombotic cardiovascular diseases. In an in vitro study, nattokinase appeared to cleave and inactivate PAI-1 in a dose-dependent manner.
✓ Improves cardiovascular health along with blood thinners
In a human clinical trial, adult patients (average 53.3 years old) with acute ischaemic stroke received 2,000 FU nattokinase NSK-SD® 3 times (total 6,000 FU) a day at 8-hour interval for 7 days. Besides, during these 7 days, 0.4ml low molecular weight heparin (anti-factor Xa, 3,800 IU) 2 times a day by hypodermic injection and low-dose aspirin (150 – 325mg) or clopidogrel were also administered. Heparin (anticoagulant drug), aspirin and clopidogrel (anti-platelet drugs) are blood thinners. All patients were hospitalized within 6 hours of stroke occurrence and the treatment was administered after hospitalization. The overall efficacy data suggests that nattokinase does not lead to progression of underlying stroke. Instead, the combined intake is suggested to enhance fibrinolysis (breaking down of blood clots) and the beneficial effects on stroke patients were observed.
In another human clinical trial, patients with cardiovascular disease (CVD) who were taking warfarin potassium tablets at a maintenance dose (1.5 < PT-INR < 3.0) received 2 doses of 1,700 FU nattokinase NSK-SD® after breakfast and dinner per day (3,4000 FU/day) or placebo for 6 months. Some of these patients showed improvement in clinical symptoms (i.e. shortness of breath, cold hands and feet) and biochemical profiles, including activated partial thromboplastin time (aPTT), prothrombin time (PT), D-dimer and plasmin inhibitor complex (PIC). No side effects were observed in all patients taking nattokinase. This study suggests that proper use of nattokinase is safe and effective for CVD patients who are taking warfarin.
Common Remedies for Circulatory Health in the Market
1) Blood Thinners (Medications)
Blood thinners are prescribed medicines that prevent blood clots from forming. They also keep existing blood clots from getting larger. There are 2 main types of blood thinners –
anticoagulants and antiplatelet drugs.
• Anticoagulants, such as heparin or warfarin slows down the body’s process of making clots.
• Antiplatelet drugs, such as aspirin or clopidogrel prevents platelets from clumping together to form a clot.
However, blood thinners may cause side effects in some people. Serious bleeding is the most common reaction - heavy periods, bleeding gums, prolonged
bleeding from a cut, etc. Other possible side effects include dizziness, muscle weakness, hair loss or rashes. Besides, the presence of blood thinners in body system can increase the risk of internal bleeding after an injury, even if external bleeding did not occur.
Although there are many types of Nattokinase available in the market, did you know that nattokinase activity may decrease when mixed with certain foods/ingredients such as red yeast rice (Monascus ruber-fermented rice). Before you make your purchase, do ensure that the supplement you chose is of pure nattokinase to ensure maximum efficacy.
Nattokinase activity may decrease to 0% when mixed with certain foods/ingredients such asblack vinegar, apple vinegar and vitamin C. Before you make your purchase, do ensure that the supplement you choose is of pure nattokinase to ensure maximum efficacy.
Did you know that natto is also linked to longevity?
(Biosci Biotechnol Biochem 77(2): 392-394 (2013)).
肠胃道需要血液来帮助消化食物并将营养素输送到身体其他部位。 当血流缓慢时，消化受到影响，这可能导致反胃、稀便和食欲不振。 纳豆激酶通过促进健康血液循环来帮助改善这些状况。