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About 350 million people worldwide suffer from joint disorder. The causes of pain include joint degeneration (a sign of ageing), inflammation, injury or just simply wear and tear from years of walking and running.
Besides the joints, muscle ache or cramp is another form of discomfort which can develop in almost all parts of the body. Muscle aches are commonly caused by stress and tension, overstrain or minor injuries sustained during exercise or physically demanding tasks.
Maintaining flexible joints and healthy mucles are vital for pain-free movement and mobility.
A joint is the connection between bones in the body, made up of five tissues: bones, cartilage, tendons, ligaments, synovium and synovial fluid. Injury or damage to any of these tissues will lead to joint discomfort such as pain, stiffness, swelling or a grinding sensation between the joints.
Years of walking, moving and exercising can take a toll on the joints and muscles, resulting in pain, stiffness and limited range of movement. Day-to-day activities such as bending over to tie a shoe lace, rising from a chair or taking a short walk may become a difficult and impact the quality of life. Hence, healthy joints and muscles are imperative for maintaining joint flexibility and mobility.
1) Cartilage loss and bone erosion – can be caused by ageing, years of walking and sports
2) Tendon injury /degeneration – can be caused by ageing, repetitive overuse or overstretching during sports or daily activities. E.g. golfing and shovelling.
3) Ligament injury / degeneration – can be caused by sharp change in direction, wrong landing from a jump or a blunt force on the knee. E.g. a football tackle.
4) Inflammation of the synovial membrane – can be caused by overuse of joint, history of trauma or injury, or abnormal immune response.
|Inflammation could lead to thickened tissue, increased blood flow to the area and increased fluid production, resulting in joint pain, tenderness & swelling|
Muscle discomfort due to muscle injury is common, symptoms include pain, weakness, bruising, swelling, spasms and cramps.
The First-Ever Bioactive Peptide Serum!
FlexC CARE Transdermal Bioactive Peptide Serum is the ‘must-have’ joint and muscle care for active and pain-free mobility. It is formulated with bioactive tetrapeptides and pentapeptides* which are developed with fermentation, hydrolysis and proprietary purification technologies to produce concentrated yet micro-molecular peptides that penetrate deeply and rapidly through the skin to effect relief to the affected areas.
*tetrapeptide is a protein peptide consisting of four amino acids and pentapeptide with five amino acids
What are Bioactive Peptides?
Bioactive Peptides are short chains of amino acids which send signals to targeted cells in the joints (e.g. cartilage cells, tendon cells) to stimulate the production of extracellular matrix (ECM) (e.g. collagen) and growth factor, both of which are important for the regeneration and repair of the joint tissues.
This scientific breakthrough formulation stimulates synthesis of extracellular matrix (ECM), including Type I & II collagens, fibronectin and growth factors, which are crucial for supporting healthy joint structures and muscles. In addition, the bioactive peptides of FlexC CARE also possess anti-inflammatory and analgesic effects to support self-repair of the joints and muscles as well as support skin health by boosting skin vitality and metabolism.
In serum form, it spreads easily and effectively. A smalldrop goes a long way.
Unprecedented benefits of FlexC CARE serum
✓ Support rapid relief from joint & muscle pain
✓ Support healthy inflammatory response
✓ Support recovery from a sprain or sports injury
✓ Stimulate ECM production to support repair and rebuild joint structures and muscles
✓ Rejuvenate, nourish and strengthen joints and muscles
✓ Support joint flexibility & active movement
What Makes FlexC CARE Superior?
• Fast absorption & deep penetration – The small Bioactive Peptides penetrate the skin and permeate to the targeted tissues to exert therapeutic and rejuvenating effects
• High concentration and Efficacy – Peptides have to be of a certain concentration to effect any benefit. FlexC CARE’s bioactive peptides are highly concentrated, only a small dosage is sufficient to produce big effects.
• Quick, long-lasting relief – Soothes discomfort within hours of application
• High purity & Safety – Bioactive Peptides are produced and purified with advanced technologies in Japan which passed SGS (safety & quality) test
• 100% free of steroids – Gentle on skin, can be applied multiple times a day. Suitable for all types of skin, including sensitive skins.
• Recognised by medical clinics around the world
• Non-greasy, non-sticky – Does not stain clothes, no sticky feeling after application
FlexC CARE serum is highly recommended for:
✓ Painful, inflamed or stiff joints due to worn-out or injured cartilage, tendons or ligaments
✓ Painful spurs on the sole
✓ Muscle strain, aches & cramps and sprains
✓ Athletes, gym-goers or active individuals (e.g. jogging, running, hiking, cycling, playing basketball, martial arts etc.)
✓ Obese or overweight whose weight can put a burden on knee joints and increase risk of cartilage loss
✓ Physically demanding jobs (e.g. construction, agriculture, cleaning and retail sectors)
✓ Middle-aged or elderly
✓ Family history of joint disorders
✓ History of physical injuries or accidents which may increase the risk of future joint problems)
✓ Rotator cuff injury* (e.g. stiff shoulder)
|Suitable to be used on joints and muscles at all body parts, including knee, back, hip, shoulder, neck, elbow, ankle, wrist, heel, hands, thigh, calf, feet, fingers, toes etc.|
# A rotator cuff injury is usually a strain or tear of the rotator cuff - the muscles, tendons and joint capsule that stabilises the shoulder. This injury can cause a dull ache on the shoulder and often worsen when one tries to sleep on the injured side.
Research-proven Benefits of the Bioactive Peptides in FlexC CARE
1) Support healthy inflammatory response
Swollen joint is one clinical feature of osteoarthritis (OA), attributed to local inflammation and thickening of synovium.
A membrane called the synovium produces a thick fluid that helps keep the cartilage healthy. The synovium can become inflamed and thickened when there is wear-and-tear on the cartilage. Inflammation causes more fluid to be produced within the joint, resulting in swelling and possibly the development of OA.
In this test, Bioactive Peptides were shown to suppress LPS-induced inflammatory response, as indicated by a reduced level of nitric oxide concentration (an inflammatory marker).
2) Promote production of extracellular matrix (ECM) for repair and regeneration
The extracellular matrix (ECM) consists of collagen, fibronectin, hyaluronic acid and other components which play a vital role in tissue repair and regeneration.
Procollagen is precursor of collagen synthesised by fibroblasts and other cells in the process of collagen synthesis. In this test, Bioactive Peptides had shown to increase synthesis of procollagen by human fibroblast.
b) Type I collagen:
Tendons and ligaments contain predominantly collagen, mostly type I to provide robust mechanical strength. Boosting collagen synthesis by fibroblast cells could potentially treat an injured tendon or ligament.
Bioactive Peptides were shown to increase type I collagen (stained brown in the diagram below) synthesis in tendon cells. The cells treated with Bioactive Peptides showed a deeper brown which indicate increased levels of type I collagen.
c) Type II collagen:
Type II collagen is a major protein in joint cartilage, the smooth, white connective tissue that covers the ends of bones as they come together to form a joint. It is believed to contribute most to tensile behaviour of the cartilage tissue.
Bioactive Peptides were shown to promote synthesis of type II collagen in human cartilage cells.
Fibronectin production appears to be an important part of cartilage, tendon, ligament and muscle healing process. In this test, Bioactive Peptides were shown to increase synthesis of fibronectin by human fibroblast.
e) Extracellular matrix (ECM):
In this clinical trial, healthy human volunteers were treated with 50ppm of Bioactive Peptides for 60 days on their buttock skin. Biopsies were taken for immunohistochemical assessment of procollagen I, hyaluronic acid and fibronectin. After 60 days, tissue staining showed a significant increase in the amount of subcutaneous collagen, hyaluronic acid and fibronectin.
In conclusion, Bioactive Peptides stimulate the synthesis of procollagen, hyaluronic acid and fibronectin, collectively known as ECM in human body.
3) Repair damaged joints
Connective tissues such as cartilage, tendons and ligaments in the joints are mostly composed of extracellular matrix (ECM). TGF-1 (a type of gene) is a well-known stimulator of ECM biosynthesis.
In this study, Bioactive Peptides were shown to synergise with TGF-1 to increase ECM biosynthesis.