I could not believe the results of the Swiss study that concluded glucosamine and chondroitin were ineffective. I've had knee pain for years, and glucosamine supplements have definitely helped. The explanation from some sources is that the analysis might not have used consistent pain management instruments, or included patients with pain too severe to benefit from glucosamine supplementation. This is believable as glucosamine did not relieve my husband's knee replacement surgery. As with a lot of medical research, the controversy continues. The best way to decide is to take it yourself and see whether you feel a difference. The flexible little old lady in the AFC Joint Sensei ad attracted my attention. How lovely to regain mobility at 80-something, so I am going to try the supplement from one of Japan's best known brands. What's interesting about Joint Sensei is the combination of not just glucosamine and chondroitin (from shark cartilage) but also ajuga extract to reduce inflammation and cat's claw for pain relief. The latter two ingredients are from plants. To make it easy to remember to take your supplement, Joint Sensei comes in 30 packs of six caplets each, enough for a month， $49.90. From pharmacies.